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Up to 25% increase in QRS duration isseen at effective doses and is usually evaluated by exercisetreadmill testing at high heart rates.61 A single dose of 300 or600 mg flecainide is used as a “pill-in-the-pocket” dosing.62Serum flecainide levels can be measured, and there is littleissue with regard to active metabolites. Thenoticed variations in the frequency of the phenotypes in dif-ferent ethnic populations (compared to Caucasian popula-tions, the percentage of slow metabolizers is higher inMiddle Eastern populations and lower in Asian populations)was also influential in the consideration of populationdifferences in drug therapeutic effectiveness and drug, andeventually environmental and occupational chemical tox-icity (toxicogenetics). For example, a different dose conversionratio should be used for cervical dystonia than for glabellar lines and for adults versuschildren. This photomicrographshows a section from a developing mandible stained with H&E. In contrast, in elbow arthroplasty, rheumatoid arthritis or posttraumatic osteoar-thritis are the most common underlying diseases. aureus (MRSA) if the local prevalence of MRSA is high. “Fermentable oli-gosaccharides, disaccharides, monosaccharides andpolyols (FODMAPS) and nonallergic food intoler-ance: FODMAPS or food chemicals?” TherapeuticAdvances in Gastroenterology, 5(4), 261–268. If factor VIII is not available—cryoprecipitate, fresh frozen plasma or fresh blood can be given.3. They decrease thefunction of T-cells, which control cellular immunity such as organ transplantrejection.

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